章海兵的个人简介
章海兵,中国科学院上海生命科学研究所营养科学研究所青年研究员。
简历:
章海兵博士1997年毕业于山东大学获学士学位;2005年毕业于中科院上海生科院健康科学研究所获博士学位。2006-2013先后在美国托马斯杰弗逊大学和费城儿童医院从事博士后研究。2013年初加入中国科学院上海生命科学研究院营养科学研究所,担任研究员、研究组长。
研究方向:
本研究组主要研究细胞凋亡和细胞程序性坏死的分子机制,以及相关的免疫调节参与代谢疾病的分子机理。研究手段和技术主要包括蛋白质组学的筛选、分子生物学、细胞生物学、基因敲除动物模型以及动物疾病模型等。通过探索细胞死亡、炎症、代谢疾病之间的关系,为疾病的治疗提供依据。
职称:
研究员
职务:
细胞死亡与免疫代谢研究组组长
代表论著:
Zhang J,Zhang H, Li J, Rosenberg S, Zhang EC, Zhou X, Qin F, Farabaugh M. RIP1-mediated regulation of lymphocyte survival and death responses.Immunol Res. 2011 Dec; 51(2-3):227-36.Cho Y, McQuade T,Zhang H, Zhang J, Chan FK. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.PLoS One. 2011;6(8):e23209. Epub 2011 Aug 10.Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes.Nature. 2011 Mar 17; 471(7338):373-6.Rosenberg S,Zhang H, Zhang J. FADD deficiency impairs early hematopoiesis in the bone marrow.J Immunol. 2011 Jan 1; 186(1):203-13.Zhang H, Hou YJ, Han SY, Zhang EC, Huebner K, Zhang J. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells.Int Immunol. 2009 Jun; 21(6):691-703.Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J.A role for cFLIP in B cell proliferation and stress MAPK regulation.J Immunol. 2009 Jan 1; 182(1):207-15.Imtiyaz HZ, Zhou X,Zhang H, Chen D, Hu T, Zhang J. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation.J Biol Chem. 2009 Apr 10; 284(15):9917-26.Zhang H, Zhang Q, Wang L, Chen H, Li Y, Cui T, Huang W, Zhang L, Yan F, Wang L, Xu Y, Hu L, Kong X.Association of IL4R gene polymorphisms with asthma in Chinese populations.Hum Mutat. 2007 Oct; 28(10):1046.Zhang H, Q Zhang, L Wang, F Yan, Y Lu, Z Wang, J Li, Y Yu, Z Zhu, X Kong, L Hu. Genetic analysis of the liver putative tumor suppressor (LPTS) gene in gastric cancer.Korean Journal of Genetics. 2005.December, 27(4):271-278.Cui B,Zhang H, Lu Y, Zhong W, Pei G, Kong X, Hu L.Refinement of the locus for non-syndromic sensorineural deafness (DFN2).J Genet. 2004 Apr; 83(1):35-8.Wang X, Liu J,Zhang H, Xiao M, Li J, Yang C, Lin X, Wu Z, Hu L, Kong X. Novel mutations in the IRF6 gene for Van der Woude syndrome.Hum Genet. 2003 Oct; 113(5):382-6.